Land for sale in South Dakota's Brule County recently totaled almost $5 million and approximately 1,000 acres. Brule County ranks 30th out of 66 counties in the Coyote State for the total acreage of land currently advertised for sale. Of all locations in Brule County with land and rural real estate for sale, Chamberlain featured the most land for sale. Its economy is defined as agricultural, with 407 farms recorded in the county during the most recent U.S. Census. Farming activities in Brule County generate annual revenues of $12 million, most of which is from crops. Brule County is the 38th largest county (846 square miles) in South Dakota. It's located in the Great Lakes South Dakota region of the state.