The combined value of farms, ranches, and rural real estate for sale in Guadalupe County recently on Land.com was $36 million. This represents 100,000 acres of land and rural real estate for sale in Guadalupe County. Guadalupe County ranks 29th out of 33 counties in the Land of Enchantment for the total number of acres of land currently advertised for sale. Santa Rosa featured the most land for sale. Based on its natural assets, tourism and recreation are important sectors for the Guadalupe County economy. Guadalupe County is the 21st biggest county (3,030 square miles) in New Mexico. It's located in the Northeast New Mexico region of New Mexico.