South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. Land for sale in Zapata County, Texas, recently totaled approximately $49 million and around 100,000 acres. Zapata County ranks 225th in Texas for the combined amount of land currently advertised for sale. Among cities in Zapata County with land and rural real estate for sale, Zapata had the most land for sale. Mining and mineral extraction-related services are the main economic drivers in this part of Texas. Zapata County is the 69th biggest county (1,058 square miles) in Texas. It's located in the Rio Grande Plains Texas region of Texas.