Land for sale in Issaquena County, Mississippi, recently totaled nearly $14 million and almost 100,000 acres. Issaquena County ranks 82nd out of 82 counties in the Hospitality State for the combined amount of land currently advertised for sale. Of all locations in Issaquena County with farms and rural real estate for sale, Fitler featured the most land for sale. Agriculture and farming drives the Issaquena County economy, with 97 farms recorded in the county during the U.S. Census in 2012. Farming activities in Issaquena County generate annual revenues of $1 million, 0 percent of which comes from crops and 0 percent from livestock bred in the county. Issaquena County is the 65th largest county (441 square miles) in Mississippi. It's located in the Delta Mississippi region of the state.