The value of all farms, hunting land and other rural land and acreage for sale in Lancaster County, South Carolina, recently was $143 million, representing a total of 2,959 acres of land for sale in Lancaster County. Lancaster County ranks 22nd out of 46 counties in South Carolina for the total acreage of land currently advertised for sale. Of all locations in Lancaster County with land and rural real estate for sale, Lancaster featured the most land for sale. Lancaster County is the 31st biggest county (555 square miles) in South Carolina. It's located in the Midlands South Carolina region of the state.